Building a sign language corpus for use in machine translation

In recent years data-driven methods of machine translation (MT) have overtaken rule-based approaches as the predominant means of automatically translating between languages. A pre-requisite for such an approach is a parallel corpus of the source and target languages. Technological developments in sign language (SL) capturing, analysis and processing tools now mean that SL corpora are becoming increasingly available. With transcription and language analysis tools being mainly designed and used for linguistic purposes, we describe the process of creating a multimedia parallel corpus specifically for the purposes of English to Irish Sign Language (ISL) MT. As part of our larger project on localisation, our research is focussed on developing assistive technology for patients with limited English in the domain of healthcare. Focussing on the first point of contact a patient has with a GP’s office, the medical secretary, we sought to develop a corpus from the dialogue between the two parties when scheduling an appointment. Throughout the development process we have created one parallel corpus in six different modalities from this initial dialogue. In this paper we discuss the multi-stage process of the development of this parallel corpus as individual and interdependent entities, both for our own MT purposes and their usefulness in the wider MT and SL research domains

Developing a Reduced Gravity Testbed for the Nanoparticle Field Extraction Thruster

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77095/1/AIAA-2009-5194-670.pd

Proteomics-Based Systems Biology Modeling of Bovine Germinal Vesicle Stage Oocyte and Cumulus Cell Interaction

BACKGROUND: Oocytes are the female gametes which establish the program of life after fertilization. Interactions between oocyte and the surrounding cumulus cells at germinal vesicle (GV) stage are considered essential for proper maturation or 'programming' of oocytes, which is crucial for normal fertilization and embryonic development. However, despite its importance, little is known about the molecular events and pathways involved in this bidirectional communication. METHODOLOGY/PRINCIPAL FINDINGS: We used differential detergent fractionation multidimensional protein identification technology (DDF-Mud PIT) on bovine GV oocyte and cumulus cells and identified 811 and 1247 proteins in GV oocyte and cumulus cells, respectively; 371 proteins were significantly differentially expressed between each cell type. Systems biology modeling, which included Gene Ontology (GO) and canonical genetic pathway analysis, showed that cumulus cells have higher expression of proteins involved in cell communication, generation of precursor metabolites and energy, as well as transport than GV oocytes. Our data also suggests a hypothesis that oocytes may depend on the presence of cumulus cells to generate specific cellular signals to coordinate their growth and maturation. CONCLUSIONS/SIGNIFICANCE: Systems biology modeling of bovine oocytes and cumulus cells in the context of GO and protein interaction networks identified the signaling pathways associated with the proteins involved in cell-to-cell signaling biological process that may have implications in oocyte competence and maturation. This first comprehensive systems biology modeling of bovine oocytes and cumulus cell proteomes not only provides a foundation for signaling and cell physiology at the GV stage of oocyte development, but are also valuable for comparative studies of other stages of oocyte development at the molecular level

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Fragments: Silkroad Returns

Pairs of Silkroad artists collaborated over the course of a month from a distance – sometimes across continents - to create brand new works. Yet another avenue for Silkroad to build bridges across traditions, these brief works are both a reflection of life in the time of a global pandemic and a celebration of creativity that brings us together. Join the artists in a lively conversation as they share high quality video of their creations and reflect on drawing inspiration from city soundscapes and elaborate knotwork of Celtic and Armenian traditions, on letting go and the therapeutic process of creating together. Founded by cellist Yo-Yo Ma in 2000, the Grammy award-winning Silkroad Ensemble has been at the core of Silkroad’s work to advance global understanding, deepen learning, and promote cross-cultural collaboration. These artists represent dozens of nationalities and artistic traditions, from Spain and Japan to Syria and the United States, and draw on a rich tapestry of traditions from around the world to create a new musical language that weaves together the foreign and the familiar. The Ensemble appears in many configurations and settings, from intimate groups of two and three in museum galleries to rousing complements of eighteen in concert halls, public squares, and amphitheaters. The Silkroad Ensemble performs throughout the world, and has recorded seven albums. Sing Me Home, which won the 2016 Grammy for Best World Music Album was developed and recorded alongside the documentary feature The Music of Strangers, from Oscar-winning director Morgan Neville. Moderated by Mark Freeman, Distinguished Professor of Ethics and Societyhttps://crossworks.holycross.edu/atb_events/1002/thumbnail.jp